Back in June, one of the hymns I sang in church was "Blessed Jesus, at Your Word." I noticed a small thing in the second verse. The first two lines are "All our knowledge, sense, and sight / Lie in deepest darkness shrouded," sung to these phrases from the tune "Liebster Jesu, wir sind hier":
The first syllable of "deepest" is sung to that E note. Because it's the lowest note in the phrase, there's a musical sense of that (metaphorical) depth.